Notice of Funding Opportunity Application Guide

The Notice of Funding Opportunity (NOFO) Application Guide provides detailed instructions for preparing and submitting your SAMHSA grant application. This guide is referenced throughout all NOFOs. Sections referenced in the NOFO will include a hyperlink that will take you directly to that information.

The Application Guide helps applicants to understand key parts of the application process, including the registration requirements, how to complete the required attachments, and prepare your budget. In addition, there is valuable information about federal policies and regulations you must follow.

If you have any questions about this information, contact the SAMHSA staff identified in Step 1 of the NOFO.

Section A: Registration and Application Submission (PDF | 456 KB)

1. Getting Started: Register on Three Required Systems
   • 1.1 System for Aware Management Registration
   • 1.2 Grants.gov Registration
   • 1.3 eRA Commons Registration
2. Complete Your Application
   • 2.1 Paper Copies of Application Materials
   • 2.2 Standard Application Components
3. Submit Your Application
   • 3.1 How to Submit Electronically
   • 3.2 How to Request a Waiver to Submit a Paper Application
   • 3.3 Deadline
   • 3.4 How to Get Assistance If You Have Trouble Submitting
4. After Submitting Your Application
   • 4.1 System Validation and Tracking
   • 4.2 System or Technical Issues

Section B: Confidentiality, Participant Safety, and Protection of Human Subjects/Services Grants (Attachment 6) (PDF | 456 KB)

1. Protect Participants and Staff from Potential Risks
2. Fair Selection of Participants
3. Absence of Coercion
4. Data Collection
5. Privacy and Confidentiality
6. Adequate Consent Procedures
7. Risk/Benefit Discussion

Section C: Confidentiality and Participant Protection/Training Grants (Attachment 6) (PDF | 456 KB)

1. Protect Participants and Staff from Potential Risks
2. Data Collection
3. Privacy and Confidentiality
4. Adequate Consent Procedures
5. Risk/Benefit Discussion

Section D: Confidentiality and Participant Protection/Capacity Building Grants (Attachment 6) (PDF | 456 KB)

1. Fair Selection of Participants
2. Data Collection
3. Privacy and Confidentiality

Section E: Budget and Narrative Justification (PDF | 456 KB)

Section F: Standards for Financial Management and Standard Funding Restrictions (PDF | 456 KB)

1. Standards for Financial Management
2. Standard Funding Restrictions

Section G: Administrative and National Policy Requirements (PDF | 456 KB)

1. HHS Grants Policy Statement (GPS)
2. HHS Award Regulations
3. Additional Terms and Conditions
4. Performance Goals and Objectives
5. Termination of Federal Award
6. Accessibility Provisions for All Award Application Packages and Funding Opportunity Announcements
7. Acknowledgement of Federal Funding
8. Supplement Not Supplant
9. Mandatory Disclosures
10. System for Award Management (SAM) Reporting
11. Drug-Free Workplace
12. Smoke-Free Workplace
13. Trafficking in Persons
14. Products Developed with Award Funds
15. Publications
16. Prohibition on Certain Telecommunications and Video Surveillance Services or Equipment

Section H: SAMHSA Expectations (PDF | 456 KB)

Section I: Behavioral Health Differential Impact Statement (DIS) (PDF | 456 KB)

1. Writing Your Behavioral Health Differential Impact Statement
2. DIS Related Terminology and Resources

Section J: Intergovernmental Review Requirements (PDF | 456 KB)

Application Guide Archive

• FY 2024 Application Guide (PDF | 535 KB)