Treatment and Support Resources for Providers

Information on evidence-based, evidence-informed, or promising models of care, fidelity, treatment, psychoeducation, peer and family support, discharge/transition planning, and engagement strategies for enrollment and retention.

Co-occurring Conditions

Recognizing Psychosis in Autism Spectrum Disorder (PDF | 300 KB)
Frontiers in Psychiatry
This paper reviews the available scientific literature about the co-occurrence of psychosis and autism, focusing attention on four specific dimensions: delusions, hallucinations, negative symptoms, and clinical course.

Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-Analysis
Journal of Autism and Developmental Disorders
This article reviews information on autism spectrum disorders (ASD) and CHR-P and includes a meta-analysis of the proportion of CHR-P in ASD.

First-Episode Psychosis and Co-Occurring Substance Use Disorders (PDF | 1.6 MB)
SAMHSA
This guide reviews the literature on treating substance misuse and substance use disorders in the context of first-episode psychosis, distills the research into recommendations for practice, and provides examples of the ways that these recommendations can be implemented by first-episode psychosis treatment programs.

Treatment Considerations for Youth and Young Adults with Serious Emotional Disturbances and Serious Mental Illnesses and Co-occurring Substance Use (PDF | 19.5 MB)
SAMHSA
This guide reviews interventions on treating substance misuse and substance use disorders (SUD) in youth with serious emotional disturbances (SED), distills the research into recommendations for practice, and provides examples of the ways that these recommendations can be implemented.

Treatment

Characterizing Covariant Trajectories of Individuals at Clinical High Risk for Psychosis Across Symptomatic and Functional Domains
The American Journal of Psychiatry
This report characterizes differences in outcomes among help-seeking individuals at CHR-P by identifying covariant longitudinal patterns of symptoms and functioning.

The Clinical High-Risk State for Psychosis (CHR-P), Version II
Schizophrenia Bulletin
This article introduces three studies that advance current knowledge on deconstructing the CHR-P paradigm across its three subgroups: genetic risk, attenuated psychotic symptoms, and short-lived and remitting psychotic episodes.

Cognitive Behavioral Therapy for Prodromal Stage of Psychosis—Outcomes for Transition, Functioning, Distress, and Quality of Life: A Systematic Review and Meta-analysis
Schizophrenia Bulletin
This study aimed to provide insight into the efficacy of CBTp in patients with CHR-P.

Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression
JAMA Psychiatry
This report compares early intervention services with treatment as usual for early-phase psychosis.

Introduction to Cognitive Behavioral Therapy for Psychosis (PDF | 1.4 MB)
Research and Training Center for Pathways to Positive Futures (Pathways RTC)
This presentation provides a background of CBTp, an overview of the evidence base, and key skills associated with CBTp, including engagement and befriending, normalizing, and curious questioning.

Clinical Practice Guideline for the Management of First-Episode Psychosis and Schizophrenia (PDF | 2 MB)
Va/DoD
This provider summary of the VA/DoD First-Episode Psychosis and Schizophrenia clinical practice guideline (CPG) provides an evidence-based framework for evaluating and managing care for patients with first-episode psychosis and schizophrenia toward improving clinical outcomes. Successful implementation of this CPG will assess the patient’s condition and collaborate with the patient, family, and caregivers to determine optimal management of patient care, emphasize the use of patient-centered care and shared decision making, minimize preventable complications and morbidity, and optimize health outcomes.

Shared Decision Making
OnTrackNY
This video series provides an overview of shared decision making, which reflects the values of collaboration, engagement, self-determination, and respect that infuse every aspect of what teams do.

Stepped Care as an Implementation and Service Delivery Model (PDF | 1.4 MB)
Community Mental Health Journal
This article describes how the stepped care model can be applied to cognitive behavioral therapy for psychosis in the U.S. to increase access to intervention in community mental health settings by leveraging the multidisciplinary team.

Symptomatic and Functional Outcomes Among Individuals at High Risk for Psychosis Participating in Step-Based Care
Psychiatric Services
This article reports outcomes from the step-based care program for individuals at CHR-P at The Ohio State University Early Psychosis Intervention Center.

The Ohio State University Early Psychosis Intervention Center (EPICENTER) Step-based Care Programme for Individuals at Clinical High Risk for Psychosis: Study Protocol for An Observational Study (PDF | 406 KB)
British Medical Journal (BMJ) Open
The article outlines the evaluation component of a step-based care program for individuals at CHR-P at The Ohio State University Early Psychosis Intervention Center—one of the twenty-one sites funded by SAMHSA to develop, implement, and evaluate such a specialized care program.

Behavioral Health Diagnoses and Treatment Services for Children Involved with the Child Welfare System
Office of the Assistant Secretary for Planning and Evaluation (ASPE)
This research brief uses claims data from the Medicaid and Children's Health Insurance Programs to examine the behavioral health diagnoses and treatment services received by children and youth involved with the child welfare system in 2019.

Post-Treatment/Continuing Care

Continuity of Care Services Following Coordinated Specialty Care: An Environmental Scan (PDF | 1.8 MB)
Office of the Assistant Secretary for Planning and Evaluation (ASPE)
This report provides an overview of transition services for clients graduating from CSC.

Support Services

The Coordinated Specialty Care Transition Study: Final Report
ASPE
This report provides an overview of transition services for clients from CSC. The report synthesizes findings from an environmental scan of programs and case studies of nine CSC programs.

Family-focused therapy for individuals at high clinical risk for psychosis: A confirmatory efficacy trial
Early Intervention in Psychiatry
This report compares the efficacy of a family-focused therapy for youth at CHR-P to a psychoeducational and supportive intervention (enhanced care) on attenuated psychotic symptoms and social functioning in individuals at CHR-P over the course of 18 months.

Implementation/Fidelity

Coordinated Specialty Care for First Episode Psychosis Manual II: Implementation (PDF | 683 KB)
NIH
This manual is designed to guide implementation of a team-based program to serve individuals who are experiencing emerging psychosis within an existing mental health clinic (MHC). It provides information on administrative issues between the team and the clinic, such as hiring team members, managing team caseloads, providing services outside of the clinic setting, using the clinic’s support staff for smooth team functioning, and sharing space and resources. Other critical implementation issues discussed involve training and ongoing supervision of team members, ways to measure fidelity to the team model, and how to build supervision and fidelity assessment into ongoing practice within the clinic.